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Publications
Bibliometrics
Manuel Mattheisen, as of October 2026. Citation figures from Scopus.
95h-index (Scopus)
~59,500citations (Scopus)
307peer-reviewed publications
27original articles as lead, senior or corresponding author
271original articles from collaborations
9reviews and book chapters
Full record: ORCID 0000-0002-8442-493X
by Manuel Mattheisen
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.
Nat Genet. 2026;58(2):275-288. doi: 10.1038/s41588-025-02485-8. PMID: 41634414
by Manuel Mattheisen
Mapping the genetic landscape across 14 psychiatric disorders.
Nature. 2026;649(8096):406-415. doi: 10.1038/s41586-025-09820-3. PMID: 41372416
by Manuel Mattheisen
Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa.
Mol Psychiatry. 2026;31(3):1475-1484. doi: 10.1038/s41380-025-03264-x. PMID: 40983652
by Manuel Mattheisen
Genome-Wide Association Study of Symptom Change Following Cognitive Behavioral Therapy for Common Mental Disorders.
Am J Med Genet B Neuropsychiatr Genet. 2026;201(6):396-405. doi: 10.1002/ajmg.b.70015. PMID: 41804033
by Manuel Mattheisen
Mental health stigma in Latin American youth with obsessive-compulsive disorder.
Psychiatry Res. 2026;361:117113. doi: 10.1016/j.psychres.2026.117113. PMID: 41933536
by Manuel Mattheisen
Methylome-Wide Association Study of Obsessive-Compulsive Disorder.
Biol Psychiatry. 2026;100(9):931-942. doi: 10.1016/j.biopsych.2026.03.1003. PMID: 41956236
by Manuel Mattheisen
Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry.
Nat Hum Behav. 2026;10(8):1-15. doi: 10.1038/s41562-026-02476-7. PMID: 42265330
by Manuel Mattheisen
Genomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes.
Nat Ment Health. 2026;4(9):1361-1377. doi: 10.1038/s44220-026-00698-2. PMID: 42718672
by Manuel Mattheisen
Frequency and Self-Reported Outcomes of Transcranial Magnetic Stimulation for Obsessive Compulsive Disorder in the U.S. and Latin America.
Rev Colomb Psiquiatr (Engl Ed). 2026. doi: 10.1016/j.rcp.2025.09.002. PMID: 42746436
by Manuel Mattheisen
Persistent tic disorders are associated with 17q12 duplications.
Mol Psychiatry. 2026. doi: 10.1038/s41380-026-03849-0. PMID: 42749776
by Manuel Mattheisen
Predictors of quality of life in OCD: Machine-derived features beyond expert consensus.
Compr Psychiatry. 2026;151:152737. doi: 10.1016/j.comppsych.2026.152737. PMID: 42790390
by Manuel Mattheisen
Cross-Ancestry Polygenic Prediction of Bipolar Disorder and Obsessive-Compulsive Disorder in India.
Am J Med Genet B Neuropsychiatr Genet. 2026. doi: 10.1002/ajmg.b.70037. PMID: 42946643
by Manuel Mattheisen
Latinos interest in knowing and using genetic risk information about obsessive compulsive disorder.
Pers Med Psychiatry. 2026;55:100171. doi: 10.1016/j.pmip.2025.100171.
by Manuel Mattheisen
Causal inference in psychiatric research: how to critically evaluate and interpret mendelian randomization studies.
Mol Psychiatry. 2026. doi: 10.1038/s41380-026-03484-9. PMID: 41673464
by Manuel Mattheisen
Genome-Wide Association Study Meta-Analysis of 9619 Cases With Tic Disorders.
Biol Psychiatry. 2025;97(7):743-752. doi: 10.1016/j.biopsych.2024.07.025. PMID: 39389409
by Manuel Mattheisen
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder.
Nat Genet. 2025;57(6):1389-1401. doi: 10.1038/s41588-025-02189-z. PMID: 40360802
by Manuel Mattheisen
The Impact of Parental Mental Health Diagnoses, Trauma, and Coping Mechanisms on Their Children's Well-Being.
Child Psychiatry Hum Dev. 2025;56(4):1074-1082. doi: 10.1007/s10578-023-01626-6.
by Manuel Mattheisen
A burden of rare copy number variants in obsessive-compulsive disorder.
Mol Psychiatry. 2025;30(4):1510-1517. doi: 10.1038/s41380-024-02763-7.
by Manuel Mattheisen
Genomics yields biological and phenotypic insights into bipolar disorder.
Nature. 2025;639(8056):968-975. doi: 10.1038/s41586-024-08468-9.
by Manuel Mattheisen
Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder.
Am J Med Genet B Neuropsychiatr Genet. 2025;198(5):e33026. doi: 10.1002/ajmg.b.33026. PMID: 40052195
by Manuel Mattheisen
Psychometric properties of the Spanish Yale-Brown Obsessive-Compulsive Scale - Second Edition.
Psychiatry Res. 2025;348:116456. doi: 10.1016/j.psychres.2025.116456. PMID: 40188616
by Manuel Mattheisen
Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses.
JAMA Psychiatry. 2025;82(8):790-800. doi: 10.1001/jamapsychiatry.2025.0828. PMID: 40341348
by Manuel Mattheisen
Benchmarking empirical severity for the Yale-Brown Obsessive Compulsive Scale-Second Edition.
J Affect Disord. 2025;390:119719. doi: 10.1016/j.jad.2025.119719. PMID: 40541829
by Manuel Mattheisen
Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Nat Med. 2025;31:3151-3168. doi: 10.1038/s41591-025-03827-z. PMID: 40691366
by Manuel Mattheisen
Transdiagnostic Links of Reward Processing in Obsessive-Compulsive Disorder and Depression.
J Affect Disord. 2025;391:119886. doi: 10.1016/j.jad.2025.119886. PMID: 40675261
by Manuel Mattheisen
Polygenic scores and symptom severity change after internet-delivered cognitive behaviour therapy for depression and anxiety.
Discov Ment Health. 2025;5:82. doi: 10.1007/s44192-025-00213-6.
by Manuel Mattheisen
Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research.
Mol Psychiatry. 2025;30(4):1627-1638. doi: 10.1038/s41380-024-02878-x. PMID: 39730880
by Manuel Mattheisen
Functional Genomics Studies of Psychiatric Disorders in Individuals of Latin American Populations: A Scoping Review.
Am J Med Genet B Neuropsychiatr Genet. 2025. doi: 10.1002/ajmg.b.33063. PMID: 41014243
by Manuel Mattheisen
Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol.
Am J Med Genet B Neuropsychiatr Genet. 2024;195(4):e32962. doi: 10.1002/ajmg.b.32962.
by Manuel Mattheisen
A polygenic resilience score moderates the genetic risk for schizophrenia: Replication in 18,090 cases and 28,114 controls from the Psychiatric Genomics Consortium.
Am J Med Genet B Neuropsychiatr Genet. 2024;195(2):e32957. doi: 10.1002/ajmg.b.32957.
by Manuel Mattheisen
The genetic architecture of youth anxiety: a study protocol.
BMC Psychiatry. 2024;24(1):159. doi: 10.1186/s12888-024-05583-9.
by Manuel Mattheisen
Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study.
Transl Psychiatry. 2024;14(1):109. doi: 10.1038/s41398-024-02811-4.
by Manuel Mattheisen
Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population.
Mol Psychiatry. 2024;29(9):2714-2723. doi: 10.1038/s41380-024-02489-6.
by Manuel Mattheisen
Shared Genetic Architecture Between Schizophrenia and Anorexia Nervosa: A Cross-trait Genome-Wide Analysis.
Schizophr Bull. 2024;50(5):1255-1265. doi: 10.1093/schbul/sbae087.
by Manuel Mattheisen
Distinct genetic liability profiles define clinically relevant patient strata across common diseases.
Nat Commun. 2024;15(1):5534. doi: 10.1038/s41467-024-49338-2.
by Manuel Mattheisen
Genetic Epidemiology and Molecular Genetics.
In Tasman A, Riba MB, Schulze TG, Ng CH, Alfonso CA, Lecic-Tosevski D, Kanba S, Alarcón RD, Ndetei DM (Eds.), Tasman’s Psychiatry. Springer Nature. 2024.
by Manuel Mattheisen
The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study.
Biol Psychiatry. 2023;93(4):362-369. doi: 10.1016/j.biopsych.2022.08.012. PMID: 36335070
by Manuel Mattheisen
Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity.
Sci Rep. 2023;13(1):429. doi: 10.1038/s41598-022-26845-0.
by Manuel Mattheisen
Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome.
Transl Psychiatry. 2023;13(1):69. doi: 10.1038/s41398-023-02341-5.
by Manuel Mattheisen
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
iScience. 2023;26(5):106701. doi: 10.1016/j.isci.2023.106701.
by Manuel Mattheisen
Polygenic risk prediction: why and when out-of-sample prediction R2 can exceed SNP-based heritability.
Am J Hum Genet. 2023;110(7):1207-1215. doi: 10.1016/j.ajhg.2023.06.006.
by Manuel Mattheisen
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.
Nat Med. 2023;29(7):1832-1844. doi: 10.1038/s41591-023-02352-1.
by Manuel Mattheisen
Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions.
Cell Genom. 2023;3(8):100356. doi: 10.1016/j.xgen.2023.100356.
by Manuel Mattheisen
Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH).
BMJ Open. 2023;13(10):e069427. doi: 10.1136/bmjopen-2022-069427.
by Manuel Mattheisen
The Genetic Architecture of Obsessive-Compulsive Disorder: Contribution of Liability to OCD From Alleles Across the Frequency Spectrum.
Am J Psychiatry. 2022;179(3):216-225. doi: 10.1176/appi.ajp.2021.21010101. PMID: 34789014
by Manuel Mattheisen
Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups.
Nat Genet. 2022;54(10):1470-1478. doi: 10.1038/s41588-022-01171-3. PMID: 36163277
by Manuel Mattheisen
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.
Biol Psychiatry. 2022;91(1):102-117. doi: 10.1016/j.biopsych.2021.02.972. PMID: 34099189
by Manuel Mattheisen
Elevated common variant genetic risk for tourette syndrome in a densely-affected pedigree.
Mol Psychiatry. 2022;27(2):1168-1175. doi: 10.1038/s41380-021-01277-w.
by Manuel Mattheisen
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.
Biol Psychiatry. 2022;91(3):313-327. doi: 10.1016/j.biopsych.2021.05.029.
by Manuel Mattheisen
Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia.
JAMA Psychiatry. 2022;79(3):260-269. doi: 10.1001/jamapsychiatry.2021.3799.
by Manuel Mattheisen
The role of early-life family composition and parental socio-economic status as risk factors for obsessive-compulsive disorder in a Danish national cohort.
J Psychiatr Res. 2022;149:18-27. doi: 10.1016/j.jpsychires.2022.02.004.
by Manuel Mattheisen
Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
Nature. 2022;604(7906):502-508. doi: 10.1038/s41586-022-04434-5.
by Manuel Mattheisen
Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis.
Nat Genet. 2022;54(5):548-559. doi: 10.1038/s41588-022-01057-4.
by Manuel Mattheisen
A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries.
Nature. 2022;610(7933):704-712. doi: 10.1038/s41586-022-05275-y. PMID: 36224396
by Manuel Mattheisen
Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System.
JAMA Psychiatry. 2022;79(11):1092-1101. doi: 10.1001/jamapsychiatry.2022.2742.
by Manuel Mattheisen
Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits.
Lancet Psychiatry. 2022;9(10):838-844. doi: 10.1016/S2215-0366(22)00157-2.
by Manuel Mattheisen
Identifying the Common Genetic Basis of Antidepressant Response.
Biol Psychiatry Glob Open Sci. 2022;2(2):115-126. doi: 10.1016/j.bpsgos.2021.07.008.
by Manuel Mattheisen
Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p.
Nat Genet. 2022;54(11):1630-1639. doi: 10.1038/s41588-022-01203-y.
by Manuel Mattheisen
Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals.
Transl Psychiatry. 2022;12(1):479. doi: 10.1038/s41398-022-02248-7.
by Manuel Mattheisen
Genomics and Epigenomics of anxiety and obsessive-compulsive disorders.
In Tsermpini EE, Alda M, Patrinos GP (Eds.), Psychiatric Genomics. Academic Press. 2022.
by Manuel Mattheisen
Polygenic Heterogeneity Across Obsessive-Compulsive Disorder Subgroups Defined by a Comorbid Diagnosis.
Front Genet. 2021;12:711624. doi: 10.3389/fgene.2021.711624. PMID: 34484301
by Manuel Mattheisen
Exemplar scoring identifies genetically separable phenotypes of lithium responsive bipolar disorder.
Transl Psychiatry. 2021;11(1):36. doi: 10.1038/s41398-020-01148-y.
by Manuel Mattheisen
Prediction of lithium response using genomic data.
Sci Rep. 2021;11(1):1155. doi: 10.1038/s41598-020-80814-z.
by Manuel Mattheisen
Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder.
Transl Psychiatry. 2021;11(1):91. doi: 10.1038/s41398-020-01121-9.
by Manuel Mattheisen
Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits.
Biol Psychiatry. 2021;89(12):1127-1137. doi: 10.1016/j.biopsych.2020.12.024.
by Manuel Mattheisen
Investigating Shared Genetic Basis Across Tourette Syndrome and Comorbid Neurodevelopmental Disorders Along the Impulsivity-Compulsivity Spectrum.
Biol Psychiatry. 2021;90(5):317-327. doi: 10.1016/j.biopsych.2020.12.028.
by Manuel Mattheisen
Antipsychotics in routine treatment are minor contributors to QT prolongation compared to genetics and age.
J Psychopharmacol. 2021;35(9):1127-1133. doi: 10.1177/02698811211003477.
by Manuel Mattheisen
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.
Nat Genet. 2021;53(6):817-829. doi: 10.1038/s41588-021-00857-4. PMID: 34002096
by Manuel Mattheisen
A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts.
Biol Psychiatry. 2021;90(9):611-620. doi: 10.1016/j.biopsych.2021.04.018.
by Manuel Mattheisen
The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.
JAMA Psychiatry. 2021;78(11):1258-1269. doi: 10.1001/jamapsychiatry.2021.2099.
by Manuel Mattheisen
A Mobile Sensing App to Monitor Youth Mental Health: Observational Pilot Study.
JMIR Mhealth Uhealth. 2021;9(10):e20638. doi: 10.2196/20638.
by Manuel Mattheisen
What Have We Learned About the Genetics of Obsessive-Compulsive and Related Disorders in Recent Years?
Focus (Am Psychiatr Publ). 2021;19(4):384-391. doi: 10.1176/appi.focus.20210017. PMID: 34690588
by Manuel Mattheisen
Genotype-phenotype feasibility studies on khat abuse, traumatic experiences and psychosis in Ethiopia.
Psychiatr Genet. 2020;30(1):34-38. doi: 10.1097/YPG.0000000000000242. PMID: 31764711
by Manuel Mattheisen
Chronicity and Sex Affect Genetic Risk Prediction in Schizophrenia.
Front Psychiatry. 2020;11:313. doi: 10.3389/fpsyt.2020.00313. PMID: 32390883
by Manuel Mattheisen
The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.
Biol Psychiatry. 2020;88(2):169-184. doi: 10.1016/j.biopsych.2019.10.015.
by Manuel Mattheisen
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank.
Mol Psychiatry. 2020;25(7):1430-1446. doi: 10.1038/s41380-019-0546-6.
by Manuel Mattheisen
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism.
Cell. 2020;180(3):568-584.e23. doi: 10.1016/j.cell.2019.12.036.
by Manuel Mattheisen
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.
Addict Biol. 2020;26(1):e12880. doi: 10.1111/adb.12880.
by Manuel Mattheisen
Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression.
Biol Psychiatry. 2020;87(5):419-430. doi: 10.1016/j.biopsych.2019.06.031.
by Manuel Mattheisen
A major role for common genetic variation in anxiety disorders.
Mol Psychiatry. 2020;25(10):2502-2513. doi: 10.1038/s41380-019-0559-1.
by Manuel Mattheisen
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder.
Mol Psychiatry. 2020;26(6):2457-2470. doi: 10.1038/s41380-020-0689-5.
by Manuel Mattheisen
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.
Nat Genet. 2020;52(5):482-493. doi: 10.1038/s41588-020-0610-9.
by Manuel Mattheisen
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank.
Nat Commun. 2020;11(1):2301. doi: 10.1038/s41467-020-16022-0.
by Manuel Mattheisen
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.
Nat Neurosci. 2020;23(7):809-818. doi: 10.1038/s41593-020-0643-5.
by Manuel Mattheisen
Complement genes contribute sex-biased vulnerability in diverse disorders.
Nature. 2020;582(7813):577-581. doi: 10.1038/s41586-020-2277-x.
by Manuel Mattheisen
Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study.
JAMA Psychiatry. 2019;76(9):924-932. doi: 10.1001/jamapsychiatry.2019.1119. PMID: 31116379
by Manuel Mattheisen
Effects of BDNF Val66Met genotype and schizophrenia familial risk on a neural functional network for cognitive control in humans.
Neuropsychopharmacology. 2019;44(3):590-597.
by Manuel Mattheisen
Genetics of response to cognitive behavior therapy in adults with major depression: a preliminary report.
Mol Psychiatry. 2019;24(4):484-490.
by Manuel Mattheisen
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.
Nat Genet. 2019;51(1):63-75.
by Manuel Mattheisen
Disentangling polygenic associations between attention-deficit/hyperactivity disorder, educational attainment, literacy and language.
Transl Psychiatry. 2019;9(1):35.
by Manuel Mattheisen
Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP.
Pharmacogenomics J. 2019;20(2):329-341. doi: 10.1038/s41397-019-0067-3.
by Manuel Mattheisen
Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder.
Am J Med Genet B. 2019;180(6):439-447.
by Manuel Mattheisen
Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia.
Am J Med Genet B. 2019;180(3):223-231.
by Manuel Mattheisen
Identification of common genetic risk variants for autism spectrum disorder.
Nat Genet. 2019;51(3):431-444.
by Manuel Mattheisen
Genetic Markers of ADHD-Related Variations in Intracranial Volume.
Am J Psychiatry. 2019;176(3):228-238.
by Manuel Mattheisen
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.
Nat Genet. 2019;51(4):659-674.
by Manuel Mattheisen
Genetic Overlap Between Alzheimer's Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes.
Front Neurosci. 2019;13:220.
by Manuel Mattheisen
Genome-wide association study identifies 30 loci associated with bipolar disorder.
Nat Genet. 2019;51(5):793-803.
by Manuel Mattheisen
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.
Nat Commun. 2019;10(1):2548.
by Manuel Mattheisen
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.
Nat Genet. 2019;51(8):1207-1214.
by Manuel Mattheisen
Nordic OCD & Related Disorders Consortium: Rationale, design, and methods.
Am J Med Genet B Neuropsychiatr Genet. 2019;183(1):38-50. doi: 10.1002/ajmg.b.32756.
by Manuel Mattheisen
A polygenic resilience score moderates the genetic risk for schizophrenia.
Mol Psychiatry. 2019;26(3):800-815. doi: 10.1038/s41380-019-0463-8.
by Manuel Mattheisen
RICOPILI: Rapid Imputation for COnsortias PIpeLIne.
Bioinformatics. 2019;36(3):930-933. doi: 10.1093/bioinformatics/btz633.
by Manuel Mattheisen
Genetic architecture of subcortical brain structures in 38,851 individuals.
Nat Genet. 2019;51(11):1624-1636. doi: 10.1038/s41588-019-0511-y.
by Manuel Mattheisen
1,25-Dihydroxyvitamin D modulates L-type voltage-gated calcium channels in a subset of neurons in the developing mouse prefrontal cortex.
Transl Psychiatry. 2019;9(1):281. doi: 10.1038/s41398-019-0626-z.
by Manuel Mattheisen
Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression.
Mol Psychiatry. 2019;26(8):4198-4209. doi: 10.1038/s41380-019-0590-2.
by Manuel Mattheisen
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.
Mol Psychiatry. 2019;26(4):1286-1298. doi: 10.1038/s41380-019-0558-2.
by Manuel Mattheisen
Autosomal-dominant hypotrichosis with woolly hair: Novel gene locus on chromosome 4q35.1-q35.2.
PLoS One. 2019;14(12):e0225943. doi: 10.1371/journal.pone.0225943.
by Manuel Mattheisen
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.
Cell. 2019;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020.
by Manuel Mattheisen
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
Nat Genet. 2018;50(5):668-681. doi: 10.1038/s41588-018-0090-3. PMID: 29700475
by Manuel Mattheisen
Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder.
Mol Psychiatry. 2018;25(9):2036-2046. doi: 10.1038/s41380-018-0115-4. PMID: 30089844
by Manuel Mattheisen
Detecting significant genotype-phenotype association rules in bipolar disorder: market research meets complex genetics.
Int J Bipolar Disord. 2018;6(1):24. doi: 10.1186/s40345-018-0132-x. PMID: 30415424
by Manuel Mattheisen
Gene set enrichment analysis and expression pattern exploration implicate an involvement of neurodevelopmental processes in bipolar disorder.
J Affect Disord. 2018;228:20-25.
by Manuel Mattheisen
A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder.
Biol Psychiatry. 2018;83(12):1044-1053.
by Manuel Mattheisen
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.
Nat Genet. 2018;50(3):381-389.
by Manuel Mattheisen
Elevated polygenic burden for autism is associated with differential DNA methylation at birth.
Genome Med. 2018;10(1):19.
by Manuel Mattheisen
Differential activity of transcribed enhancers in the prefrontal cortex of 537 cases with schizophrenia and controls.
Mol Psychiatry. 2018;24(11):1685-1695. doi: 10.1038/s41380-018-0059-8.
by Manuel Mattheisen
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood.
Am J Hum Genet. 2018;102(6):1185-1194.
by Manuel Mattheisen
Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder.
Front Psychiatry. 2018;9:207.
by Manuel Mattheisen
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes.
Cell. 2018;173(7):1705-1715.e16.
by Manuel Mattheisen
Analysis of shared heritability in common disorders of the brain.
Science. 2018;360(6395).
by Manuel Mattheisen
Age at first birth in women is genetically associated with increased risk of schizophrenia.
Sci Rep. 2018;8(1):10168.
by Manuel Mattheisen
Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis.
Transl Psychiatry. 2018;8(1):204.
by Manuel Mattheisen
Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2018;4(1):91-100.
by Manuel Mattheisen
The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods.
Contemp Clin Trials. 2018;74:61-69.
by Manuel Mattheisen
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder.
Commun Biol. 2018;1:163.
by Manuel Mattheisen
The association between neonatal vitamin D status and risk of schizophrenia.
Sci Rep. 2018;8(1):17692.
by Manuel Mattheisen
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.
Nat Genet. 2017;49(1):27-35.
by Manuel Mattheisen
Association of the polygenic risk score for schizophrenia with mortality and suicidal behavior - A Danish population-based study.
Schizophr Res. 2017;184:122-127.
by Manuel Mattheisen
Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.
J Cachexia Sarcopenia Muscle. 2017;8(3):428-436.
by Manuel Mattheisen
The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders.
Mol Psychiatry. 2017;23(2):400-412. doi: 10.1038/mp.2016.231.
by Manuel Mattheisen
Functional neuroimaging effects of recently discovered genetic risk loci for schizophrenia and polygenic risk profile in five RDoC subdomains.
Transl Psychiatry. 2017;7(1):e997.
by Manuel Mattheisen
Novel genetic loci associated with hippocampal volume.
Nat Commun. 2017;8:13624.
by Manuel Mattheisen
Identification of shared risk loci and pathways for bipolar disorder and schizophrenia.
PLoS One. 2017;12(2):e0171595.
by Manuel Mattheisen
Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder.
Transl Psychiatry. 2017;7(2):e1034.
by Manuel Mattheisen
Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.
Alcohol Clin Exp Res. 2017;41(5):911-928.
by Manuel Mattheisen
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.
Nat Commun. 2017;8:14774.
by Manuel Mattheisen
Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci.
Hum Mol Genet. 2017;26(10):1942-1951.
by Manuel Mattheisen
Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD).
Front Mol Neurosci. 2017;10:83.
by Manuel Mattheisen
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders.
Nat Genet. 2017;49(7):978-985.
by Manuel Mattheisen
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
Mol Autism. 2017;8:21.
by Manuel Mattheisen
The 5-HTTLPR Polymorphism Affects Network-Based Functional Connectivity in the Visual-Limbic System in Healthy Adults.
Neuropsychopharmacology. 2017;43(2):406-414. doi: 10.1038/npp.2017.121.
by Manuel Mattheisen
Polygenic risk score and heritability estimates reveals a genetic relationship between ASD and OCD.
Eur Neuropsychopharmacol. 2017;27(7):657-666.
by Manuel Mattheisen
Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis.
Mol Psychiatry. 2017;23(5):1181-1188. doi: 10.1038/mp.2017.154.
by Manuel Mattheisen
Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations.
JAMA Psychiatry. 2017;74(12):1214-1225.
by Manuel Mattheisen
Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes.
Sci Rep. 2017;7(1):15351.
by Manuel Mattheisen
Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium.
Biol Psychiatry. 2017;84(2):138-147.
by Manuel Mattheisen
Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants.
JAMA Psychiatry. 2016;73(4):369-77. doi: 10.1001/jamapsychiatry.2015.3018. PMID: 26963595
by Manuel Mattheisen
Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness.
Am J Med Genet B. 2016;171B(2):276-89.
by Manuel Mattheisen
Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.
Lancet. 2016;387(10023):1085-93.
by Manuel Mattheisen
Schizophrenia risk from complex variation of complement component 4.
Nature. 2016;530(7589):177-83.
by Manuel Mattheisen
Mortality Among Persons With Obsessive-Compulsive Disorder in Denmark.
JAMA Psychiatry. 2016;73(3):268-74.
by Manuel Mattheisen
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
Nat Neurosci. 2016;19(3):420-31.
by Manuel Mattheisen
Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population.
Nat Genet. 2016;48(5):552-5.
by Manuel Mattheisen
DNA Methylation at the Neonatal State and at the Time of Diagnosis: Preliminary Support for an Association with the Estrogen Receptor 1, Gamma-Aminobutyric Acid B Receptor 1, and Myelin Oligodendrocyte Glycoprotein in Female Adolescent Patients with OCD.
Front Psychiatry. 2016;7:35.
by Manuel Mattheisen
Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells.
Cell Rep. 2016;15(5):1024-36.
by Manuel Mattheisen
Identification of the BRD1 interaction network and its impact on mental disorder risk.
Genome Med. 2016;8(1):53.
by Manuel Mattheisen
Altered Functional Subnetwork During Emotional Face Processing: A Potential Intermediate Phenotype for Schizophrenia.
JAMA Psychiatry. 2016;73(6):598-605.
by Manuel Mattheisen
Specific anxiety disorders and subsequent risk for bipolar disorder: a nationwide study.
World Psychiatry. 2016;15(2):187-8.
by Manuel Mattheisen
Polygenic Risk Scores on the Association Between Infections and Schizophrenia.
Biol Psychiatry. 2016;80(8):609-16.
by Manuel Mattheisen
Increased mortality among people with anxiety disorders: total population study.
Br J Psychiatry. 2016;209(3):216-21.
by Manuel Mattheisen
Schizophrenia risk variants affecting microRNA function and site-specific regulation of NT5C2 by miR-206.
Eur Neuropsychopharmacol. 2016;26(9):1522-1526.
by Manuel Mattheisen
Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1.
Mol Neurobiol. 2016;54(7):5166-5176.
by Manuel Mattheisen
Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data.
Genom Data. 2016;10:22-9.
by Manuel Mattheisen
Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.
Mol Psychiatry. 2016;21(11):1608-1612.
by Manuel Mattheisen
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.
PLoS Genet. 2016;12(10):e1006343.
by Manuel Mattheisen
Novel genetic loci underlying human intracranial volume identified through genome-wide association.
Nat Neurosci. 2016;19(12):1569-1582.
by Manuel Mattheisen
Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function.
Schizophr Bull. 2015;41(6):1294-308. doi: 10.1093/schbul/sbv017. PMID: 25759474
by Manuel Mattheisen
High loading of polygenic risk in cases with chronic schizophrenia.
Mol Psychiatry. 2015;21(7):969-74. doi: 10.1038/mp.2015.130. PMID: 26324100
by Manuel Mattheisen
Secondary depression in severe anxiety disorders: a population-based cohort study in Denmark.
Lancet Psychiatry. 2015;2(6):515–523. doi: 10.1016/S2215-0366(15)00092-9. PMID: 26360447
by Manuel Mattheisen
Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder.
J Clin Psychiatry. 2015;76(2):128-34.
by Manuel Mattheisen
Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene.
Ann Am Thorac Soc. 2015;12(3):332-9.
by Manuel Mattheisen
Hypomethylation and increased expression of the putative oncogene ELMO3 are associated with lung cancer development and metastases formation.
Oncoscience. 2015;1(5):367-74.
by Manuel Mattheisen
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways.
Nat Neurosci. 2015;18(2):199-209.
by Manuel Mattheisen
Common genetic variants influence human subcortical brain structures.
Nature. 2015;520(7546):224-9.
by Manuel Mattheisen
Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.
Nat Commun. 2015;6:6031.
by Manuel Mattheisen
Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder.
Am J Hum Genet. 2015;96(2):283-94.
by Manuel Mattheisen
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.
Nat Genet. 2015;47(3):291-5.
by Manuel Mattheisen
Genome-wide association study and meta-analysis identify ISL1 as genome-wide significant susceptibility gene for bladder exstrophy.
PLoS Genet. 2015;11(3):e1005024.
by Manuel Mattheisen
Whole-genome association analysis of treatment response in obsessive-compulsive disorder.
Mol Psychiatry. 2015;21(2):270-6.
by Manuel Mattheisen
Polygenic Risk Score, Parental Socioeconomic Status, Family History of Psychiatric Disorders, and the Risk for Schizophrenia: A Danish Population-Based Study and Meta-analysis.
JAMA Psychiatry. 2015;72(7):635-41.
by Manuel Mattheisen
MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits.
Am J Med Genet B. 2015;168B(4):296-306.
by Manuel Mattheisen
The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25,000 subjects.
Mol Psychiatry. 2015;20(6):735-43.
by Manuel Mattheisen
Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders.
Neuron. 2015;86(5):1189-202.
by Manuel Mattheisen
A Novel Locus for Ectodermal Dysplasia of Hair, Nail and Skin Pigmentation Anomalies Maps to Chromosome 18p11.32-p11.31.
PLoS One. 2015;10(6):e0129811.
by Manuel Mattheisen
New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.
Int J Epidemiol. 2015;44(5):1706-21.
by Manuel Mattheisen
Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance.
Br J Psychiatry. 2015;208(2):128-37.
by Manuel Mattheisen
Diagnosed Anxiety Disorders and the Risk of Subsequent Anorexia Nervosa: A Danish Population Register Study.
Eur Eat Disord Rev. 2015;23(6):524-30.
by Manuel Mattheisen
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.
Behav Genet. 2015;46(2):151-69.
by Manuel Mattheisen
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.
Am J Hum Genet. 2015;97(4):576-92.
by Manuel Mattheisen
Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder.
Transl Psychiatry. 2015;5:e678.
by Manuel Mattheisen
Obsessive-Compulsive Disorder and Autism Spectrum Disorders: Longitudinal and Offspring Risk.
PLoS One. 2015;10(11):e0141703.
by Manuel Mattheisen
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
BMC Genet. 2015;16:138.
by Manuel Mattheisen
Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis.
Nat Genet. 2015;47(12):1385-92.
by Manuel Mattheisen
Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.
Mol Psychiatry. 2014;20(3):337-44. doi: 10.1038/mp.2014.43. PMID: 24821223
by Manuel Mattheisen
Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder.
Hum Mol Genet. 2014;23(20):5536-44. doi: 10.1093/hmg/ddu259. PMID: 24852367
by Manuel Mattheisen
Integrated pathway-based approach identifies association between genomic regions at CTCF and CACNB2 and schizophrenia.
PLoS Genet. 2014;10(6):e1004345. doi: 10.1371/journal.pgen.1004345. PMID: 24901509
by Manuel Mattheisen
Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks.
Hum Hered. 2014;78(3-4):131-9. doi: 10.1159/000365589. PMID: 25171373
by Manuel Mattheisen
Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene.
Mol Psychiatry. 2014;19(7):774-83.
by Manuel Mattheisen
Further evidence for the impact of a genome-wide-supported psychosis risk variant in ZNF804A on the Theory of Mind Network.
Neuropsychopharmacology. 2014;39(5):1196-205.
by Manuel Mattheisen
Genetic variation in the lymphotoxin-α (LTA)/tumour necrosis factor-α (TNFα) locus as a risk factor for idiopathic achalasia.
Gut. 2014;63(9):1401-9.
by Manuel Mattheisen
Efficient strategy for detecting gene × gene joint action and its application in schizophrenia.
Genet Epidemiol. 2014;38(1):60-71.
by Manuel Mattheisen
A genetic deconstruction of neurocognitive traits in schizophrenia and bipolar disorder.
PLoS One. 2014;8(12):e81052.
by Manuel Mattheisen
Gender-specific association of variants in the AKR1C1 gene with dimensional anxiety in patients with panic disorder: additional evidence for the importance of neurosteroids in anxiety?
Depress Anxiety. 2014;31(10):843-50.
by Manuel Mattheisen
The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion.
Cell Metab. 2014;19(2):310-8.
by Manuel Mattheisen
Genome-wide association study reveals two new risk loci for bipolar disorder.
Nat Commun. 2014;5:3339.
by Manuel Mattheisen
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.
Lancet Respir Med. 2014;2(3):214-25.
by Manuel Mattheisen
Striatal response to reward anticipation: evidence for a systems-level intermediate phenotype for schizophrenia.
JAMA Psychiatry. 2014;71(5):531-9.
by Manuel Mattheisen
Replication of brain function effects of a genome-wide supported psychiatric risk variant in the CACNA1C gene and new multi-locus effects.
Neuroimage. 2014;94:147-54.
by Manuel Mattheisen
Identification of pathways for bipolar disorder: a meta-analysis.
JAMA Psychiatry. 2014;71(6):657-64.
by Manuel Mattheisen
Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.
Am J Respir Cell Mol Biol. 2014;51(5):678-87.
by Manuel Mattheisen
Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway.
JAMA Psychiatry. 2014;71(7):778-85.
by Manuel Mattheisen
Investigation of the involvement of MIR185 and its target genes in the development of schizophrenia.
J Psychiatry Neurosci. 2014;39(6):386-96.
by Manuel Mattheisen
GWAS-based pathway analysis differentiates between fluid and crystallized intelligence.
Genes Brain Behav. 2014;13(7):663-74.
by Manuel Mattheisen
αCaMKII autophosphorylation controls the establishment of alcohol drinking behavior.
Neuropsychopharmacology. 2014;38(9):1636-47.
by Manuel Mattheisen
Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia.
Nat Genet. 2014;46(8):901-4.
by Manuel Mattheisen
XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans.
Neuropsychopharmacology. 2014;40(2):361-71.
by Manuel Mattheisen
Analysis of t(9;17)(q33.2;q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder.
Bipolar Disord. 2014;17(2):205-11.
by Manuel Mattheisen
Biological insights from 108 schizophrenia-associated genetic loci.
Nature. 2014;511(7510):421-7.
by Manuel Mattheisen
Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene.
Respir Res. 2014;15:89.
by Manuel Mattheisen
IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.
Am J Respir Cell Mol Biol. 2014;52(3):365-76.
by Manuel Mattheisen
Common and rare variant analysis in early-onset bipolar disorder vulnerability.
PLoS One. 2014;9(8):e104326.
by Manuel Mattheisen
DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease.
Respir Res. 2014;15:97.
by Manuel Mattheisen
Investigation of manic and euthymic episodes identifies state- and trait-specific gene expression and STAB1 as a new candidate gene for bipolar disorder.
Transl Psychiatry. 2014;4:e426.
by Manuel Mattheisen
Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene.
Respir Med. 2014;108(10):1469-80.
by Manuel Mattheisen
Obsessive-compulsive disorder as a risk factor for schizophrenia: a nationwide study.
JAMA Psychiatry. 2014;71(11):1215-21.
by Manuel Mattheisen
Airway wall thickness is increased in COPD patients with bronchodilator responsiveness.
Respir Res. 2014;15:84.
by Manuel Mattheisen
Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease.
Ann Am Thorac Soc. 2014;11(9):1387-94.
by Manuel Mattheisen
Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus.
BMC Pulm Med. 2014;14:164.
by Manuel Mattheisen
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases.
Am J Hum Genet. 2014;95(5):535-52.
by Manuel Mattheisen
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.
Brain Imaging Behav. 2014;8(2):153-82. doi: 10.1007/s11682-013-9269-5.
by Manuel Mattheisen
Functional and genetic characterization of the non-lysosomal glucosylceramidase 2 as a modifier for Gaucher disease.
Orphanet J Rare Dis. 2013;8:151. doi: 10.1186/1750-1172-8-151. PMID: 24070122
by Manuel Mattheisen
Genetic schizophrenia risk variants jointly modulate total brain and white matter volume.
Biol Psychiatry. 2013;73(6):525-31.
by Manuel Mattheisen
Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility.
Schizophr Res. 2013;142(1-3):200-5.
by Manuel Mattheisen
Common variant at 16p11.2 conferring risk of psychosis.
Mol Psychiatry. 2013;19(1):108-14.
by Manuel Mattheisen
No evidence for an involvement of copy number variation in ABCA13 in schizophrenia, bipolar disorder, or major depressive disorder.
Psychiatr Genet. 2013;23(1):45-6.
by Manuel Mattheisen
Duplications in RB1CC1 are associated with schizophrenia; identification in large European sample sets.
Transl Psychiatry. 2013;3:e326.
by Manuel Mattheisen
Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci.
Mol Psychiatry. 2013;19(3):325-33.
by Manuel Mattheisen
Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors.
Am J Hum Genet. 2013;92(2):197-209.
by Manuel Mattheisen
Schizophrenia genetic variants are not associated with intelligence.
Psychol Med. 2013;43(12):2563-70. doi: 10.1017/S0033291713000196.
by Manuel Mattheisen
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
Lancet. 2013;381(9875):1371-9.
by Manuel Mattheisen
Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.
Mol Psychiatry. 2013;19(4):452-61.
by Manuel Mattheisen
All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs.
PLoS Genet. 2013;9(4):e1003449.
by Manuel Mattheisen
On association analysis of rare variants under population substructure: an approach for the detection of subjects that can cause bias in the analysis - T opt: an outlier detection method.
Genet Epidemiol. 2013;37(5):431-9.
by Manuel Mattheisen
Rare autosomal copy number variations in early-onset familial Alzheimer's disease.
Mol Psychiatry. 2013;19(6):676-81.
by Manuel Mattheisen
Copy number variants in German patients with schizophrenia.
PLoS One. 2013;8(7):e64035.
by Manuel Mattheisen
Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support.
Transl Psychiatry. 2013;3:e287.
by Manuel Mattheisen
Candidate gene association study implicates p63 in the etiology of non syndromic bladder-exstrophy-epispadias complex.
Birth Defects Res A Clin Mol Teratol. 2013;97(12):759-63.
by Manuel Mattheisen
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
Nat Genet. 2013;45(9):984-94.
by Manuel Mattheisen
Integrated genome-wide pathway association analysis with INTERSNP.
Hum Hered. 2012;73(2):63-72. doi: 10.1159/000336196. PMID: 22399020
by Manuel Mattheisen
Linkage-disequilibrium-based binning affects the interpretation of GWASs.
Am J Hum Genet. 2012;90(4):727-33. doi: 10.1016/j.ajhg.2012.02.025. PMID: 22444669
by Manuel Mattheisen
Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder.
Schizophr Res. 2012;138(1):69-73. doi: 10.1016/j.schres.2012.03.007. PMID: 22497794
by Manuel Mattheisen
Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia.
Schizophr Res. 2012;141(2-3):262-5. doi: 10.1016/j.schres.2012.08.027. PMID: 23017826
by Manuel Mattheisen
FZD6 encoding the Wnt receptor frizzled 6 is mutated in autosomal-recessive nail dysplasia.
Br J Dermatol. 2012;166(5):1088-94.
by Manuel Mattheisen
Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample.
Am J Med Genet B. 2012;159B(3):263-73.
by Manuel Mattheisen
Gene-based analysis of regionally enriched cortical genes in GWAS data sets of cognitive traits and psychiatric disorders.
PLoS One. 2012;7(2):e31687.
by Manuel Mattheisen
A mega-analysis of genome-wide association studies for major depressive disorder.
Mol Psychiatry. 2012;18(4):497-511.
by Manuel Mattheisen
Role of common and rare APP DNA sequence variants in Alzheimer disease.
Neurology. 2012;78(16):1250-7.
by Manuel Mattheisen
Identification of common variants associated with human hippocampal and intracranial volumes.
Nat Genet. 2012;44(5):552-61.
by Manuel Mattheisen
Common variants at 12q14 and 12q24 are associated with hippocampal volume.
Nat Genet. 2012;44(5):545-51.
by Manuel Mattheisen
Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.
PLoS Genet. 2012;8(4):e1002656.
by Manuel Mattheisen
DCLK1 variants are associated across schizophrenia and attention deficit / hyperactivity disorder.
PLoS One. 2012;7(4):e35424.
by Manuel Mattheisen
Segment-wise genome-wide association analysis identifies a candidate region associated with schizophrenia in three independent samples.
PLoS One. 2012;7(6):e38828.
by Manuel Mattheisen
Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis.
PLoS One. 2012;7(6):e37852.
by Manuel Mattheisen
Neuregulin 3 is associated with attention deficits in schizophrenia and bipolar disorder.
Int J Neuropsychopharmacol. 2012;16(3):549-56.
by Manuel Mattheisen
Replication of functional serotonin receptor type 3A and B variants in bipolar affective disorder: a European multicenter study.
Transl Psychiatry. 2012;2:e103.
by Manuel Mattheisen
Genome-wide meta-analyses of non syndromic cleft lip with or without cleft palate identify six new risk loci.
Nat Genet. 2012;44(9):968-71.
by Manuel Mattheisen
Genome-wide association data provide further support for an association between 5-HTTLPR and major depressive disorder.
J Affect Disord. 2012;146(3):438-40.
by Manuel Mattheisen
Studies in humans and mice implicate neurocan in the etiology of mania.
Am J Psychiatry. 2012;169(9):982-90.
by Manuel Mattheisen
Quick, "imputation-free" meta-analysis with proxy-SNPs.
BMC Bioinformatics. 2012;13:231.
by Manuel Mattheisen
Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1.
Transl Psychiatry. 2012;2:e165.
by Manuel Mattheisen
Nine new twin pairs with esophageal atresia: a review of the literature and performance of a twin study of the disorder.
Birth Defects Res A Clin Mol Teratol. 2012;94(3):182-6. doi: 10.1002/bdra.22879.
by Manuel Mattheisen
VATER/VACTERL association: identification of seven new twin pairs, a systematic review of the literature, and a classical twin analysis.
Clin Dysmorphol. 2012;21(4):191-5. doi: 10.1097/MCD.0b013e328358455c.
by Manuel Mattheisen
Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe.
Mol Psychiatry. 2011;17(9):906-17. doi: 10.1038/mp.2011.80. PMID: 21747397
by Manuel Mattheisen
Significance levels in genome-wide interaction analysis (GWIA).
Ann Hum Genet. 2011;75(1):29-35.
by Manuel Mattheisen
Resequencing and follow-up of neurexin 1 (NRXN1) in schizophrenia patients.
Schizophr Res. 2011;127(1-3):35-40.
by Manuel Mattheisen
Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder.
Am J Hum Genet. 2011;88(3):372-81.
by Manuel Mattheisen
Genome-wide survey implicates the influence of copy number variants (CNVs) in the development of early-onset bipolar disorder.
Mol Psychiatry. 2011;17(4):421-32.
by Manuel Mattheisen
The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.
Biol Psychiatry. 2011;70(1):35-42.
by Manuel Mattheisen
Common variants at VRK2 and TCF4 conferring risk of schizophrenia.
Hum Mol Genet. 2011;20(20):4076-81.
by Manuel Mattheisen
Association of COMT genotypes with S-COMT promoter methylation in growth-discordant monozygotic twins and healthy adults.
BMC Med Genet. 2011;12:115.
by Manuel Mattheisen
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
Nat Genet. 2011;43(10):977-83.
by Manuel Mattheisen
Genome-wide association study identifies five new schizophrenia loci.
Nat Genet. 2011;43(10):969-76.
by Manuel Mattheisen
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
Addict Biol. 2011;17(1):171-80.
by Manuel Mattheisen
Hippocampal function in healthy carriers of the CLU Alzheimer's disease risk variant.
J Neurosci. 2011;31(49):18180-4.
by Manuel Mattheisen
Genome-wide association study identifies two susceptibility loci for non syndromic cleft lip with or without cleft palate.
Nat Genet. 2010;42(1):24-6.
by Manuel Mattheisen
Expanding the range of ZNF804A variants conferring risk of psychosis.
Mol Psychiatry. 2010;16(1):59-66.
by Manuel Mattheisen
Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.
Nat Genet. 2010;42(2):128-31.
by Manuel Mattheisen
A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry.
Schizophr Res. 2010;118(1-3):98-105.
by Manuel Mattheisen
Independent evidence for the selective influence of GABA(A) receptors on one component of the bipolar disorder phenotype.
Mol Psychiatry. 2010;16(6):587-9.
by Manuel Mattheisen
The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sample.
Schizophr Res. 2010;122(1-3):24-30.
by Manuel Mattheisen
Evidence for linkage of the bladder exstrophy-epispadias complex on chromosome 4q31.21-22 and 19q13.31-41 from a consanguineous Iranian family.
Birth Defects Res A. 2010;88(9):757-61.
by Manuel Mattheisen
Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression.
Biol Psychiatry. 2010;68(6):578-85.
by Manuel Mattheisen
Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples.
Mol Psychiatry. 2009;15(5):463-72.
by Manuel Mattheisen
Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter.
Schizophr Res. 2009;111(1-3):123-30.
by Manuel Mattheisen
A novel locus for arterial hypertension on chromosome 1p36 maps to a metabolic syndrome trait cluster in the Sorbs, a Slavic population isolate in Germany.
J Hypertens. 2009;27(5):983-90.
by Manuel Mattheisen
The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations.
Hum Mol Genet. 2009;18(14):2719-27.
by Manuel Mattheisen
Common variants conferring risk of schizophrenia.
Nature. 2009;460(7256):744-7.
by Manuel Mattheisen
Supporting evidence for LRRTM1 imprinting effects in schizophrenia.
Mol Psychiatry. 2009;14(8):743-5.
by Manuel Mattheisen
Genome-wide linkage scan of non syndromic orofacial clefting in 91 families of central European origin.
Am J Med Genet A. 2009;149A(12):2680-94.
by Manuel Mattheisen
Inferential testing for linkage with GENEHUNTER-MODSCORE: the impact of the pedigree structure on the null distribution of multipoint MOD scores.
Genet Epidemiol. 2008;32(1):73-83. doi: 10.1002/gepi.20264. PMID: 17849490
by Manuel Mattheisen
Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder.
Hum Mol Genet. 2008;17(1):87-97.
by Manuel Mattheisen
Linkage analysis using sex-specific recombination fractions with GENEHUNTER-MODSCORE.
Bioinformatics. 2007;23(1):64-70.
by Manuel Mattheisen
Explorative two-locus linkage analysis suggests a multiplicative interaction between the 7q32 and 16p13 myoclonic seizures-related photosensitivity loci.
Genet Epidemiol. 2007;31(1):42-50.
by Manuel Mattheisen
A German genome-wide linkage scan for type 2 diabetes supports the existence of a metabolic syndrome locus on chromosome 1p36.13 and a type 2 diabetes locus on chromosome 16p12.2.
Diabetologia. 2007;50(7):1418-22.
by Manuel Mattheisen
High factor VIII levels in venous thromboembolism show linkage to imprinted loci on chromosomes 5 and 11.
Blood. 2005 Jan 15;105(2):638-44. doi: 10.1182/blood-2004-05-2018. Epub 2004 Sep 7.PMID: 15353485
by Manuel Mattheisen
Genetic dissection of photosensitivity and its relation to idiopathic generalized epilepsy.
Ann Neurol. 2005;57(6):866-73.